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| ¡¡ Microfabrication of Liver Tissueª²Engineered
Scaffold Abstract£ºBy simulating the internal microarchitectures in liver£¬tissueª²engineered
scaffold with microchambers and microchannels was designed to facilitate the regeneration
of liver tissue£® Stereolithography (SL) and microimprint techniques were employed to
manufacture siliconª²rubber mould and the biodegradable chitosan/gelatin composite
scaffold was patterned via microreplication technique£® The results show that the
conventional SL and maskª²based SL processes enable to build the microstructures with the
scale below 200 ¦Ìm£®The microª²SL process was endowed with the capability to fabricate
three kinds of microstructures simultaneously£ºhepatic chambers (200-300¦Ìm)£¬
blood vessel channels (100-200 ¦Ìm) and microchannels (13.1-30¦Ìm)£®These
microstructures are constructed on the same mould with satisfied replication accuracy and
edge features£® The microfabrication method based on SL and microreplication techniques
provides a new way to fabricate complex liver tissueª²engineered scaffold and ensures an
orderly distribution of different hepatic cells£® |
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