Liu Yaxiong1,Li Dichen2,Lu Bingheng2,Sun Minglin3,Wang Zhen3,Wang Jue1
(1.The Key Laboratory of Biomedical Information Engineering of Ministry of Education,Xi'an Jiaotong University,Xi'an 710049,China;2.State Key Laboratory for Manufacturing System Engineering,Xi'an¡¡Jiaotong¡¡University,Xi'an 710049,China;3. Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China)
Abstract£ºA new artificial bone composed of calcium phosphate cement (CPC)¡Mbone morphogenetic protein (BMP)¡Mtitanium frame is proposed to improve the strength of CPC¡MBMP. An animal experiment of half a year and the succeeding research motivate a degrading model for this implant. The results confirm that the porosity of the implant increases logarithmically; the surface porosity is notably lower than the central porosity;the boundary between the two ports of the implant and fresh bone presents two bathtub curve because of a large phagedena degradation; the titanium frame can promote the strength of the implant without essentially slowing the holistic degradation and the implant can be expected to beemployed clinically in large bone repair. The conclusions provide an experimental basis for the titanium frame.
Keywords£ºcalcium phosphate cement; bone morphogenetic protein; porosity; degradation; titaniumframe